menu

Molecular traffic key to keeping cellular highways maintained

Biomolecular motors transporting cargo within the cells found to wear down intracellular highways, prompting autonomous repair

In living cells, biomolecular motors act as vehicles to transport intracellular cargo along molecular highways of microtubules. But while damage to typical roads caused by cars and trucks is periodically repaired by paving work, relatively little is known about the degradation and maintenance of their molecular counterparts.

Now, researchers in Japan and France studying mixtures of the biomaterials in the lab have discovered that biomolecular motors also wear down microtubule highways and that the damage is fixed through a self-repair process.

The building blocks of microtubules are tubulin heterodimers—units consisting of two different proteins. Within the microtubule shaft, tubulin units adopt a densely packed and highly ordered crystal-like lattice structure, which is generally considered to be stable.

To walk along these microtubules, biomolecular motors such as kinesin and dynein convert the chemical energy of the molecule adenosine triphosphate (ATP) into motion. However, it has been unclear how the force exerted by these biomolecular motors impacts the shaft stability and dynamics of microtubules.

In a study published in Nature Materials, researchers revealed in reconstituted systems using purified biomaterials that the mechanical action of biomolecular motors can remove tubulin from the microtubule shaft and rapidly destroy them. Moreover, this effect was not observed when free tubulins were present in the system thanks to self-repair through the insertion of new free tubulins into the areas damaged by the biomolecular motors.

In addition to preventing the destruction of microtubules traversed by biomolecular motors through the maintenance of roads that have been used, the self-repair contributes to the rejuvenation of the microtubules by replacing old tubulins in the lattice with fresh ones.

“Thanks to this mechanism, the more microtubules are traversed by biomolecular motors, the more they undergo self-repair, thus rejuvenating and strengthening them,” says Daisuke Inoue, one of the lead authors on the study and assistant professor at Kyushu University’s Faculty of Design. “Essentially, this mechanism promotes transportation and can transform frequently used small roads into highways.”

Such self-repair and rejuvenation processes are associated with many biological functions, playing roles in our health and the pathways of various diseases, so the researchers plan to explore more applications of the microtubule’s self-repair in not only biological but also medical science.

Details

Please visit here.

UCSD-Kyushu U Joint Webinar:SDGs THINK and ACT together

The Booklet of SDGs Design International Awards 2020

Related post

  1. Acceptance and Commitmen…

    Division for Humanities and Social Sci…

  2. Globalization of the Cit…

    Faculty of LawAssoci. Prof. Toru Oga…

  3. Development of 3D Graphi…

    Innovation Center for Educational Reso…

  4. Effects of Pre-Cooling o…

    Faculty of DesignProfessor Takafumi …

  5. Kyushu University Librar…

    Kyushu University Library signs cooper…

  6. The Coming of a ‘D…

    International Student CenterProf. M…

  7. The psychology of entomo…

    Kyushu University Institute for Asian …

  8. Exercise reverses cognit…

    Cognitive deficiencies caused by pedia…

PAGE TOP